The Scientific Challenge Spring 2023 comes to a conclusion: Martin Schwalm from the University of Frankfurt wins with his project Identifying Binders to Hijack the Autophagy System for Targeted Protein Degradation! The study aimed to identify binders for the LC3A proteins hydrophobic binding site, a crucial target for drug discovery within the Atg8 protein family. Utilizing a library of approximately 8500 compounds, virtual screening identified potential binders, subsequently validated through fluorescence polarization screening. Ultimately, two non-covalent binders with Ki ≤ 10 µM were identified. NMR spectroscopy confirmed binding to the hydrophobic binding site. Additionally, a structure-based screening approach using X-ray crystallography identified two novel binding sites (S1 and S2) on LC3B, with S1 being particularly promising for future drug discovery efforts. We extend our congratulations to Martin for his exemplary and comprehensive study, which has provided valuable insights into potential drug targets within the LC3/GABARAP protein family. Furthermore, we wish him the greatest success in his future career and hope to see the study soon as a peer-review publication! Read more about his project following this link. The preprint to the publication can be found here.
Kotlin The beauty of Kotlin type system kt.academyGood explanation of the type system Java Java: S
zum Artikel gehenSmilla ist German Winner 2022. CACIB, KfT + VDH CAC, BOS Wir freuen uns, dass Smilla am 10. Juli 2022 ihr letztes CACIB fr den Titel Internationaler Schnheitschampion erhalten hat. Die Voraussetzungen sind nun mit der Jahresf
zum Artikel gehenKotlin Simplify Your Kotlin Code with Scope Functions: Unleashing the Power of Objects SUNIL KVNice overview of the scope functions.
zum Artikel gehenKotlin Effective Kotlin: Item 14 —Consider implementing Comparable Matthew DolanHow to use comparable in ranges and as iteratorsExciting Future of Kotlin: K2 Compiler Sevban BayırInteress
zum Artikel gehenTotally crazy n funny Princess Spring Breakers Trailer. (~Rebellin~)Media: Video
zum Artikel gehen